index of 1391 (vol 15&16)

Npgrj_nn_1549 1391..1400

In the phenomenon of attentional blink, identical visual stimuli are sometimes fully perceived and sometimes not detected at all. This phenomenon thus provides an optimal situation to study the fate of stimuli not consciously perceived and the differences between conscious and nonconscious processing. We correlated behavioral visibility ratings and recordings of event-related potentials to stud...

Jcb_201704017 1513..1516

1513 The Rockefeller University Press $30.00 J. Cell Biol. Vol. 216 No. 6 1513–1515 https://doi.org/10.1083/jcb.201704017 Ionic homeostasis and ion transport are essential for all life forms on Earth. Well defined concentrations of key ions, most commonly Na+, K+, Cl−, Ca2+, and H+, are maintained not only in the cytoplasm and extracellular space but also inside subcellular organelles. Ionic gr...

Dmd058602 1379..1391

Cytochrome P450 (P450) induction is often considered a liability in drug development. Using calibration curve–based approaches, we assessed the induction parameters R3 (a term indicating the amount of P450 induction in the liver, expressed as a ratio between 0 and 1), relative induction score, Cmax/EC50, and area under the curve (AUC)/F2 (the concentration causing 2-fold increase from baseline ...

Dmd064436 1381..1391

CT7758, a carboxylate containing a4b1/a4/b7 integrin antagonist, was characterized for its pharmacokinetic profile in various in vitro and in vivo assays in support of clinical development. The oral bioavailability of CT7758 was 4% in mice, 2% in rats, 7–55% in dogs, and 0.2% in cynomolgus monkeys. The low bioavailability in rodents and monkey results from low intestinal absorption as evidenced...

Dev119065 1516..1527

Mesoderm formation and subsequent anterior-posterior (A-P) axis elongation are fundamental aspects of gastrulation, which is initiated by formation of the primitive streak (PS). Convergent extension (CE) movementsandepithelial-mesenchymal transition (EMT)are important for A-P axis elongation in vertebrate embryos. The evolutionarily conserved planar cell polarity (PCP) pathway regulates CE, and...

Author Index Vol. 22, Suppl. 1, 2013